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Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral

Iron is concentrated in ferritin, a spherical protein with a capacious cavity for ferric nanominerals of <4,500 Fe atoms. Global ferritin structure is very stable, resisting 6 M urea and heat (85°C) at neutral pH. Eight pores, each formed by six helices from 3 of the 24 polypeptide subunits, rest...

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Detalhes bibliográficos
Main Authors: Liu, Xiaofeng, Jin, Weili, Theil, Elizabeth C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152977/
https://ncbi.nlm.nih.gov/pubmed/12634425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0636928100
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