Frequency of Mutation to Rifampin Resistance in Streptococcus pneumoniae Clinical Strains: hexA and hexB Polymorphisms Do Not Account for Hypermutation

The frequency of mutation to rifampin resistance of 200 clinical Streptococcus pneumoniae isolates was examined. Two peaks were observed in the distribution, with mode frequencies of 2.5 × 10(−7) (20% of isolates) and 2.5 × 10(−8). The hexA and hexB gene entire sequences were analyzed in 13 isolates...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Morosini, María-Isabel, Baquero, María-Rosario, Sánchez-Romero, J. M., Negri, María-Cristina, Galán, Juan-Carlos, del Campo, Rosa, Pérez-Díaz, J. C., Baquero, Fernando
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2003
Témata:	Mechanisms of Resistance
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152530/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1464-1467.2003
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