Frequency of Mutation to Rifampin Resistance in Streptococcus pneumoniae Clinical Strains: hexA and hexB Polymorphisms Do Not Account for Hypermutation

The frequency of mutation to rifampin resistance of 200 clinical Streptococcus pneumoniae isolates was examined. Two peaks were observed in the distribution, with mode frequencies of 2.5 × 10(−7) (20% of isolates) and 2.5 × 10(−8). The hexA and hexB gene entire sequences were analyzed in 13 isolates...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Morosini, María-Isabel, Baquero, María-Rosario, Sánchez-Romero, J. M., Negri, María-Cristina, Galán, Juan-Carlos, del Campo, Rosa, Pérez-Díaz, J. C., Baquero, Fernando
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Assuntos:	Mechanisms of Resistance
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152530/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1464-1467.2003
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