Frequency of Mutation to Rifampin Resistance in Streptococcus pneumoniae Clinical Strains: hexA and hexB Polymorphisms Do Not Account for Hypermutation

The frequency of mutation to rifampin resistance of 200 clinical Streptococcus pneumoniae isolates was examined. Two peaks were observed in the distribution, with mode frequencies of 2.5 × 10(−7) (20% of isolates) and 2.5 × 10(−8). The hexA and hexB gene entire sequences were analyzed in 13 isolates...

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Bibliographic Details
Main Authors: Morosini, María-Isabel, Baquero, María-Rosario, Sánchez-Romero, J. M., Negri, María-Cristina, Galán, Juan-Carlos, del Campo, Rosa, Pérez-Díaz, J. C., Baquero, Fernando
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC152530/
https://ncbi.nlm.nih.gov/pubmed/12654695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1464-1467.2003
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