Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity

In this work, the role of HDAC6, a type II histone deacetylase with tubulin deacetylase activity, in lymphocyte polarity, motility, and transmigration was explored. HDAC6 was localized at dynamic subcellular structures as leading lamellipodia and the uropod in migrating T-cells. However, HDAC6 activ...

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Bibliografiske detaljer
Main Authors: Cabrero, J. Román, Serrador, Juan M., Barreiro, Olga, Mittelbrunn, María, Naranjo-Suárez, Salvador, Martín-Cófreces, Noa, Vicente-Manzanares, Miguel, Mazitschek, Ralph, Bradner, James E., Ávila, Jesús, Valenzuela-Fernández, Agustín, Sánchez-Madrid, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525231/
https://ncbi.nlm.nih.gov/pubmed/16738306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0008
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