An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

BACKGROUND: Vav proteins are guanine nucleotide exchange factors (GEF) for Rho family GTPases and are activated following engagement of membrane receptors. Overexpression of Vav proteins enhances lamellipodium and ruffle formation, migration, and cell spreading, and augments activation of many downs...

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Autores principales: Wilsbacher, Julie L, Moores, Sheri L, Brugge, Joan S
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1524963/
https://ncbi.nlm.nih.gov/pubmed/16709244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-4-5
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