Tissue Penetration by Ertapenem, a Parenteral Carbapenem Administered Once Daily, in Suction-Induced Skin Blister Fluid in Healthy Young Volunteers

The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 μg/ml (the MIC at which 90% of the isolates tested are...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Laethem, T., De Lepeleire, I., McCrea, J., Zhang, J., Majumdar, A., Musson, D., Rogers, D., Li, S., Guillaume, M., Parneix-Spake, A., Deutsch, P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654688/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1439-1442.2003
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