Tissue Penetration by Ertapenem, a Parenteral Carbapenem Administered Once Daily, in Suction-Induced Skin Blister Fluid in Healthy Young Volunteers

The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 μg/ml (the MIC at which 90% of the isolates tested are...

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Main Authors: Laethem, T., De Lepeleire, I., McCrea, J., Zhang, J., Majumdar, A., Musson, D., Rogers, D., Li, S., Guillaume, M., Parneix-Spake, A., Deutsch, P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152496/
https://ncbi.nlm.nih.gov/pubmed/12654688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1439-1442.2003
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