Generation and characterization of the humoral immune response to DNA immunization with a chimeric β-amyloid-interleukin-4 minigene

Active immunization with fibrillar β–amyloid peptide (Aβ(42)) as well as passive transfer of anti-Aβ antibodies significantly reduces Aβ plaque deposition, neuritic dystrophy, and astrogliosis in the brain of mutant amyloid precursor protein (APP)-transgenic mice. Although the mechanism(s) of cleara...

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Main Authors: Ghochikyan, Anahit, Vasilevko, Vitaly, Petrushina, Irina, Movsesyan, Nina, Babikyan, Davit, Tian, Wenqiang, Sadzikava, Nadya, Ross, TedM., Head, Elizabeth, Cribbs, David H., Agadjanyan, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1524857/
https://ncbi.nlm.nih.gov/pubmed/14635031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200324000
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