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In Vivo Pharmacodynamics of HMR 3270, a Glucan Synthase Inhibitor, in a Murine Candidiasis Model

In vivo pharmacokinetic/pharmacodynamic characterization for numerous antibacterial compounds has had a significant impact upon optimal dosing regimen design and the development of in vivo susceptibility breakpoints. More recently, similar characterization has been undertaken for antifungal drug cla...

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Published in:Antimicrob Agents Chemother
Main Authors: Andes, D., Marchillo, K., Lowther, J., Bryskier, A., Stamstad, T., Conklin, R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152480/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654645/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1187-1192.2003
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