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Proteinuria precedes podocyte abnormalities inLamb2(–/–) mice, implicating the glomerular basement membrane as an albumin barrier
Primary defects in either podocytes or the glomerular basement membrane (GBM) cause proteinuria, a fact that complicates defining the barrier to albumin. Laminin β2 (LAMB2) is a GBM component required for proper functioning of the glomerular filtration barrier. To investigate the GBM’s role in glome...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2006
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1523402/ https://ncbi.nlm.nih.gov/pubmed/16886065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28414 |
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