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Proteinuria precedes podocyte abnormalities inLamb2(–/–) mice, implicating the glomerular basement membrane as an albumin barrier

Primary defects in either podocytes or the glomerular basement membrane (GBM) cause proteinuria, a fact that complicates defining the barrier to albumin. Laminin β2 (LAMB2) is a GBM component required for proper functioning of the glomerular filtration barrier. To investigate the GBM’s role in glome...

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Bibliografiska uppgifter
Huvudupphovsmän: Jarad, George, Cunningham, Jeanette, Shaw, Andrey S., Miner, Jeffrey H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2006
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523402/
https://ncbi.nlm.nih.gov/pubmed/16886065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28414
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