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A positive feedback loop couples Ras activation and CD44 alternative splicing
The Ras signaling pathway is important in both cell proliferation and tumor progression. Alternatively spliced isoforms of CD44 containing variable exon 6 (v6) can serve as coreceptors for growth factor receptors that activate Ras. Here we use v6-specific small interfering RNA (siRNA) to investigate...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1522067/ https://ncbi.nlm.nih.gov/pubmed/16818603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1430906 |
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