A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs

An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an “elongation” mutant that destabilizes...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Fodor, Ervin, Mingay, Louise J., Crow, Mandy, Deng, Tao, Brownlee, George G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Replication
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663810/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.5017-5020.2003
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