A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs

An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an “elongation” mutant that destabilizes...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Fodor, Ervin, Mingay, Louise J., Crow, Mandy, Deng, Tao, Brownlee, George G.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2003
Gaiak:	Replication
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663810/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.5017-5020.2003
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