A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs

An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an “elongation” mutant that destabilizes...

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Bibliographic Details
Main Authors: Fodor, Ervin, Mingay, Louise J., Crow, Mandy, Deng, Tao, Brownlee, George G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC152145/
https://ncbi.nlm.nih.gov/pubmed/12663810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.5017-5020.2003
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