Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin

Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-ac...

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發表在:	Infect Immun
Principais autores:	Jounblat, Rania, Kadioglu, Aras, Mitchell, Tim J., Andrew, Peter W.
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2003
主題:	Bacterial Infections
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.4.1813-1819.2003
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