Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin

Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-ac...

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Bibliographische Detailangaben
Hauptverfasser: Jounblat, Rania, Kadioglu, Aras, Mitchell, Tim J., Andrew, Peter W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Bacterial Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152068/
https://ncbi.nlm.nih.gov/pubmed/12654795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.4.1813-1819.2003
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