Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin

Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-ac...

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Detalhes bibliográficos
Main Authors: Jounblat, Rania, Kadioglu, Aras, Mitchell, Tim J., Andrew, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152068/
https://ncbi.nlm.nih.gov/pubmed/12654795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.4.1813-1819.2003
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