Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites.

In rats exposed to a single intraperitoneal dose of 200 mg/kg of the environmental carcinogen benzo[a]pyrene (BP) in sunflower oil, significant individual variations in excretion of the BP activation (BP-7,8-diol) and deactivation (3-OH-BP) derivatives were found. Most rats developed peritoneal sarc...

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Main Authors: Likhachev, A J, Beniashvili, D Sh, Bykov, V J, Dikun, P P, Tyndyk, M L, Savochkina, I V, Yermilov, V B, Zabezhinski, M A
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1519633/
https://ncbi.nlm.nih.gov/pubmed/1336725
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