Nitric oxide synthase in cardiac sarcoplasmic reticulum

NO(⋅) is a free radical that modulates heart function and metabolism. We report that a neuronal-type NO synthase (NOS) is located on cardiac sarcoplasmic reticulum (SR) membrane vesicles and that endogenous NO(⋅) produced by SR-associated NOS inhibits SR Ca(2+) uptake. Ca(2+)-dependent biochemical c...

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Bibliografiska uppgifter
Huvudupphovsmän: Xu, Kai Y., Huso, David L., Dawson, Ted M., Bredt, David S., Becker, Lewis C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1999
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC15192/
https://ncbi.nlm.nih.gov/pubmed/9892689
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