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Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

Besides synthesizing nitric oxide (NO), purified neuronal NO synthase (nNOS) can produce superoxide (.O2-) at lower L-Arg concentrations. By using electron paramagnetic resonance spin-trapping techniques, we monitored NO and .O2- formation in nNOS-transfected human kidney 293 cells. In control trans...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Xia, Y, Dawson, V L, Dawson, T M, Snyder, S H, Zweier, J L
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39102/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692893/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6770
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