Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-e...

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Bibliographic Details
Main Authors: Wang, Chenguang, Li, Zhiping, Lu, Yinan, Du, Runlei, Katiyar, Sanjay, Yang, Jianguo, Fu, Maofu, Leader, Jennifer E., Quong, Andrew, Novikoff, Phyllis M., Pestell, Richard G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518800/
https://ncbi.nlm.nih.gov/pubmed/16864783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603363103
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