Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-e...

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Autors principals: Wang, Chenguang, Li, Zhiping, Lu, Yinan, Du, Runlei, Katiyar, Sanjay, Yang, Jianguo, Fu, Maofu, Leader, Jennifer E., Quong, Andrew, Novikoff, Phyllis M., Pestell, Richard G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518800/
https://ncbi.nlm.nih.gov/pubmed/16864783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603363103
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