Tertiary Structural Rearrangements upon Oxidation of Methionine(145) in Calmodulin Promotes Targeted Proteasomal Degradation

The selectivity underlying the recognition of oxidized calmodulin (CaM) by the 20S proteasome in complex with Hsp90 was identified using mass spectrometry. We find that degradation of oxidized CaM (CaM(ox)) occurs in a multistep process, which involves an initial cleavage that releases a large N-ter...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sacksteder, Colette A., Whittier, Jennifer E., Xiong, Yijia, Li, Jinhui, Galeva, Nadezhda A., Jacoby, Michael E., Purvine, Samuel O., Williams, Todd D., Rechsteiner, Martin C., Bigelow, Diana J., Squier, Thomas C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Biophysical Society 2006
Pynciau:
Proteins
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518657/
https://ncbi.nlm.nih.gov/pubmed/16751245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.086033
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