Tertiary Structural Rearrangements upon Oxidation of Methionine(145) in Calmodulin Promotes Targeted Proteasomal Degradation

The selectivity underlying the recognition of oxidized calmodulin (CaM) by the 20S proteasome in complex with Hsp90 was identified using mass spectrometry. We find that degradation of oxidized CaM (CaM(ox)) occurs in a multistep process, which involves an initial cleavage that releases a large N-ter...

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Detalhes bibliográficos
Main Authors: Sacksteder, Colette A., Whittier, Jennifer E., Xiong, Yijia, Li, Jinhui, Galeva, Nadezhda A., Jacoby, Michael E., Purvine, Samuel O., Williams, Todd D., Rechsteiner, Martin C., Bigelow, Diana J., Squier, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518657/
https://ncbi.nlm.nih.gov/pubmed/16751245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.086033
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