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Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice

Acute liver failure caused by viral hepatitis or toxic damage involves both apoptotic and necrotic pathways. IGF binding protein-1 (IGFBP-1), a hepatocyte-derived secreted protein, is required for normal liver regeneration. To determine whether IGFBP-1 could prevent liver injury that entails direct...

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Udgivet i:J Clin Invest
Principais autores: Leu, Julia I., Crissey, Mary Ann S., Taub, Rebecca
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151838/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12511596/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16712
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