Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice

Acute liver failure caused by viral hepatitis or toxic damage involves both apoptotic and necrotic pathways. IGF binding protein-1 (IGFBP-1), a hepatocyte-derived secreted protein, is required for normal liver regeneration. To determine whether IGFBP-1 could prevent liver injury that entails direct...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Leu, Julia I., Crissey, Mary Ann S., Taub, Rebecca
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2003
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12511596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16712
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