Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice

We have developed a rapid new in vivo method for screening experimental drugs for their activity against Mycobacterium tuberculosis by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of acti...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lenaerts, Anne J. M., Gruppo, Veronica, Brooks, Jason V., Orme, Ian M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12543692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.2.783-785.2003
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