The Growth Factor Granulin Interacts with Cyclin T1 and Modulates P-TEFb-Dependent Transcription

Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. Cyclin T1...

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Bibliographic Details
Main Authors: Hoque, Mainul, Young, Tara M., Lee, Chee-Gun, Serrero, Ginette, Mathews, Michael B., Pe'ery, Tsafi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151712/
https://ncbi.nlm.nih.gov/pubmed/12588988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.5.1688-1702.2003
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