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ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter.

Transcription from the HIV-1 LTR promoter efficiently initiates but rapidly terminates because of a non-processive form of RNA polymerase II. This premature termination is overcome by assembly of an HIV-1 TAT/P-TEFb complex at the transactivation response region (TAR), a structured RNA element encod...

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Principais autores: James W Bruce, Rachel Reddington, Elizabeth Mathieu, Megan Bracken, John A T Young, Paul Ahlquist
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-10-01
Serier:PLoS Pathogens
Online adgang:http://europepmc.org/articles/PMC3812036?pdf=render
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