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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cer...

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Detalhes bibliográficos
Main Authors: Limbourg, Florian P., Huang, Zhihong, Plumier, Jean-Christophe, Simoncini, Tommaso, Fujioka, Masayuki, Tuckermann, Jan, Schütz, Günther, Moskowitz, Michael A., Liao, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151626/
https://ncbi.nlm.nih.gov/pubmed/12464678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15481
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