Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cer...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Limbourg, Florian P., Huang, Zhihong, Plumier, Jean-Christophe, Simoncini, Tommaso, Fujioka, Masayuki, Tuckermann, Jan, Schütz, Günther, Moskowitz, Michael A., Liao, James K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2002
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC151626/
https://ncbi.nlm.nih.gov/pubmed/12464678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15481
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