Eukaryotic Initiation Factors 4G and 4A Mediate Conformational Changes Downstream of the Initiation Codon of the Encephalomyocarditis Virus Internal Ribosomal Entry Site

Initiation of translation of encephalomyocarditis virus mRNA is mediated by an internal ribosome entry site (IRES) comprising structural domains H, I, J-K, and L immediately upstream of the initiation codon AUG at nucleotide 834 (AUG(834)). Assembly of 48S ribosomal complexes on the IRES requires eu...

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Bibliographic Details
Main Authors: Kolupaeva, Victoria G., Lomakin, Ivan B., Pestova, Tatyana V., Hellen, Christopher U. T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151537/
https://ncbi.nlm.nih.gov/pubmed/12509466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.2.687-698.2003
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