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Structure of a cholesterol-binding protein deficient in Niemann–Pick type C2 disease
Niemann–Pick disease type C2 (NP-C2) is a fatal hereditary disease characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Here we report the 1.7-Å resolution crystal structure of the cholesterol-binding protein deficient in this disease, NPC2, and the characteriza...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151372/ https://ncbi.nlm.nih.gov/pubmed/12591954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437840100 |
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