Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
The affinity of the extracellular domain of integrins for ligand is regulated by conformational changes signaled from the cytoplasm. Alternative types of conformational movement in the ligand-binding headpiece have been proposed. In one study, electron micrograph image averages of the headpiece of i...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0438060100 |
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