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Role of the conserved NPxxY(x)(5,6)F motif in the rhodopsin ground state and during activation
In the G protein-coupled receptor rhodopsin, the conserved NPxxY(x)(5,6)F motif connects the transmembrane helix VII and the cytoplasmic helix 8. The less geometrically constrained retinal analogue 9-demethyl-retinal prevents efficient transformation of rhodopsin to signaling metarhodopsin (Meta) II...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151333/ https://ncbi.nlm.nih.gov/pubmed/12601165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0435715100 |
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