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Role of the conserved NPxxY(x)(5,6)F motif in the rhodopsin ground state and during activation

In the G protein-coupled receptor rhodopsin, the conserved NPxxY(x)(5,6)F motif connects the transmembrane helix VII and the cytoplasmic helix 8. The less geometrically constrained retinal analogue 9-demethyl-retinal prevents efficient transformation of rhodopsin to signaling metarhodopsin (Meta) II...

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Dettagli Bibliografici
Autori principali: Fritze, Olaf, Filipek, Sławomir, Kuksa, Vladimir, Palczewski, Krzysztof, Hofmann, Klaus Peter, Ernst, Oliver P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC151333/
https://ncbi.nlm.nih.gov/pubmed/12601165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0435715100
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