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Mutation of Phe318 within the NPxxY(x)(5,6)F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity

Melanin-concentrating hormone receptor 1 (MCHR1) is a G-protein-coupled receptor (GPCR) that plays an important role in feeding by coupling to Gα(q)- and Gα(i)-mediated signal transduction pathways. To interrogate the molecular basis for MCHR1 activation, we analyzed the effect of a series of site-d...

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Detalles Bibliográficos
Main Authors: Hamamoto, Akie, Horikawa, Manabu, Saho, Tomoko, Saito, Yumiko
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515998/
https://ncbi.nlm.nih.gov/pubmed/23233849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2012.00147
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