Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

Under conditions of limited oxygen availability (hypoxia), multiple cell types release adenine nucleotides in the form of ATP, ADP, and AMP. Extracellular AMP is metabolized to adenosine by surface-expressed ecto-5′-nucleotidase (CD73) and subsequently activates surface adenosine receptors regulatin...

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Main Authors: Synnestvedt, Kristin, Furuta, Glenn T., Comerford, Katrina M., Louis, Nancy, Karhausen, Jorn, Eltzschig, Holger K., Hansen, Karl R., Thompson, Linda F., Colgan, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC151145/
https://ncbi.nlm.nih.gov/pubmed/12370277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15337
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