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Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

Under conditions of limited oxygen availability (hypoxia), multiple cell types release adenine nucleotides in the form of ATP, ADP, and AMP. Extracellular AMP is metabolized to adenosine by surface-expressed ecto-5′-nucleotidase (CD73) and subsequently activates surface adenosine receptors regulatin...

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Detalhes bibliográficos
Main Authors: Synnestvedt, Kristin, Furuta, Glenn T., Comerford, Katrina M., Louis, Nancy, Karhausen, Jorn, Eltzschig, Holger K., Hansen, Karl R., Thompson, Linda F., Colgan, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151145/
https://ncbi.nlm.nih.gov/pubmed/12370277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15337
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