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Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

Different members of the Rel/NF-κB family may play different roles in immunity and inflammation. We report here that c-Rel–deficient mice are resistant to autoimmune encephalomyelitis and are defective in Th1, but not Th2 responses. The Th1 deficiency appears to be caused by selective blockade of IL...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hilliard, Brendan A., Mason, Nicola, Xu, Lingyun, Sun, Jing, Lamhamedi-Cherradi, Salah-Eddine, Liou, Hsiou-Chi, Hunter, Christopher, Chen, Youhai H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC151124/
https://ncbi.nlm.nih.gov/pubmed/12235116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15254
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