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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein. Using mi...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2002
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151109/ https://ncbi.nlm.nih.gov/pubmed/12208864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15795 |
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