Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein. Using mi...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151109/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15795 |
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