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Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

Graves disease is directly caused by thyroid-stimulating autoantibodies (TSAb’s) that activate the thyrotropin receptor (TSHR). We observed upon flow cytometry using intact cells that a mouse mAb (3BD10) recognized the TSHR ectodomain with a glycosidylphosphatidylinositol (ECD-GPI) anchor approximat...

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Udgivet i:J Clin Invest
Principais autores: Chazenbalk, Gregorio D., Pichurin, Pavel, Chen, Chun-Rong, Latrofa, Francesco, Johnstone, Alan P., McLachlan, Sandra M., Rapoport, Basil
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151066/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12122113/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15745
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