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Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

In gastrointestinal epithelium, metaplastic conversion between predominant cell types is associated with an increased risk of neoplasia. However, the mechanisms regulating metaplastic transitions in adult epithelia are largely undefined. Here we show that matrix metalloproteinase-7 (MMP-7) is expres...

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Udgivet i:J Clin Invest
Principais autores: Crawford, Howard C., Scoggins, Charles R., Washington, M. Kay, Matrisian, Lynn M., Leach, Steven D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150998/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12045257/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15051
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