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Pneumocysterol [(24Z)-ethylidenelanost-8-en-3β-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: Structural identity and chemical synthesis

Pneumocystis carinii pneumonia (PcP) remains among the most prevalent opportunistic infections among AIDS patients. Currently, drugs used clinically for deep mycosis act by binding ergosterol or disrupting its biosynthesis. Although classified as a fungus, P. carinii lacks ergosterol. Instead, the p...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kaneshiro, Edna S., Amit, Zunika, Swonger, Mardie M., Kreishman, George P., Brooks, Elwood E., Kreishman, Mara, Jayasimhulu, Koka, Parish, Edward J., Sun, Hang, Kizito, Stephen A., Beach, David H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15099/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874778/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.97
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