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Mapping myasthenia gravis–associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice

Susceptibility to myasthenia gravis (MG) is positively linked to expression of HLA-DQ8 and DR3 molecules and negatively linked to expression of the DQ6 molecule. To elucidate the molecular basis of this association, we have induced experimental autoimmune MG (EAMG) in mice transgenic for HLA-DQ8, DQ...

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Udgivet i:J Clin Invest
Principais autores: Yang, Huan, Goluszko, Elzbieta, David, Chella, Okita, David K., Conti-Fine, Bianca, Chan, Teh-sheng, Poussin, Mathilde A., Christadoss, Premkumar
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150946/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11956249/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14255
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