IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis

Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic therapeutic potential of IL-7 in both in vitro and in vivo pulmonary fibrosis models. IL-7 inhibited both TGF...

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Autori principali: Huang, Min, Sharma, Sherven, Zhu, Li X., Keane, Michael P., Luo, Jie, Zhang, Ling, Burdick, Marie D., Lin, Ying Q., Dohadwala, Mariam, Gardner, Brian, Batra, Raj K., Strieter, Robert M., Dubinett, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150933/
https://ncbi.nlm.nih.gov/pubmed/11927620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14685
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