Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion

Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product prostaglandin E2 (PGE2) and its signaling through the EP4 receptor in mediating non-small cell lung cancer (NSCLC) invasiveness...

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Detalhes bibliográficos
Main Authors: Dohadwala, Mariam, Batra, Raj K., Luo, Jie, Lin, Ying, Krysan, Kostyantyn, Põld, Mehis, Sharma, Sherven, Dubinett, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1471886/
https://ncbi.nlm.nih.gov/pubmed/12393872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M210707200
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