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P-selectin glycoprotein ligand-1–deficient mice have impaired leukocyte tethering to E-selectin under flow

P-selectin glycoprotein ligand-1 (PSGL-1) mediates rolling of leukocytes on P-selectin under flow. The glycoproteins that enable leukocyte tethering to or rolling on E-selectin are not known. We used gene targeting to prepare PSGL-1–deficient (PSGL-1(–/–)) mice, which were healthy but had moderately...

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I publikationen:J Clin Invest
Huvudupphov: Xia, Lijun, Sperandio, Markus, Yago, Tadayuki, McDaniel, J. Michael, Cummings, Richard D., Pearson-White, Sonia, Ley, Klaus, McEver, Rodger P.
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Clinical Investigation 2002
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11927621/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14151
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