Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death

Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune response and has been demonstrated in cardiomyocytes in septic shock, myocarditis, transplant rejection, ischemia, and dilated cardiomyopathy. To explore whether the consequences of such expression are adaptive...

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Main Authors: Mungrue, Imran N., Gros, Robert, You, Xiaomang, Pirani, Asif, Azad, Azar, Csont, Tamas, Schulz, Richard, Butany, Jagdish, Stewart, Duncan J., Husain, Mansoor
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150906/
https://ncbi.nlm.nih.gov/pubmed/11901182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13265
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