Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis

Glatiramer acetate (GA; Copaxone) is a random copolymer of glutamic acid, lysine, alanine, and tyrosine that is used therapeutically in patients with multiple sclerosis (MS). To investigate the mechanism of the drug’s immunomodulatory effect, we used immunophenotypic approaches to characterize the p...

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Detalhes bibliográficos
Main Authors: Karandikar, Nitin J., Crawford, Michael P., Yan, Xiao, Ratts, Robert B., Brenchley, Jason M., Ambrozak, David R., Lovett-Racke, Amy E., Frohman, Elliot M., Stastny, Peter, Douek, Daniel C., Koup, Richard A., Racke, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150895/
https://ncbi.nlm.nih.gov/pubmed/11877472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14380
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